Centre research publications from 2020. SpEDIT: A fast and efficient CRISPR/Cas9 method for fission yeast Allshire lab paper featured in Wellcome Open Research. Integrative vectors for regulated expression of SARS-CoV-2 proteins implicated in RNA metabolism Tollervey lab paper featured in Wellcome Open Research. The mRNA m6A reader YTHDF2 supresses pro-inflammatory pathways and sustains hematopoietic stem cell function O'Carroll lab paper featured in the Journal of Experimental Medicine. The proteomic landscape of centromeric chromatin reveals an essential role for the Ctf19CCAN complex in meiotic kinetochore assembly Paper from the Marston lab featured in Current Biology. Stress-Induced Translation Inhibition through Rapid Displacement of Scanning Initiation Factors Tollervey lab paper featured in Molecular Cell. Large domains of heterochromatin direct the formation of short mitotic chromosome loops Allshire lab paper featured in eLife. Epigenetic gene silencing by heterochromatin primes fungal resistance Allshire lab paper featured in Nature. In-cell architecture of an actively transcribing-translating expressome Rappsilber lab paper featured in Science. TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing O'Carroll lab paper featured in Nature Communications. H3K9me3 maintenance on a human artificial chromosome is required for segregation but not centromere epigenetic memory Earnshaw lab paper featured in the Journal of Cell Science. SPOCD1 is an essential executor of piRNA-directed de novo DNA methylation O'Carroll lab paper featured in Nature. The C-terminal helix of BubR1 is essential for CENP-E-dependent chromosome alignment Welburn lab paper featured in Journal of Cell Science. Nascent Transcript Folding Plays a Major Role in Determining RNA Polymerase Elongation Rates Tollervey lab paper featured in Molecular Cell. Substrate Specificity of the TRAMP Nuclear Surveillance Complexes Tollervey lab paper featured in Nature Communications. Spt6 is a maintenance factor for centromeric CENP-A Heun lab paper featured in Nature Communications. Cyclin A triggers Mitosis either via the Greatwall kinase pathway or Cyclin B A collaborative study between the Hochegger (Sussex), Novak (Oxford) and Ly groups investigated the specialised functions of two mitotic cyclin types, cyclin A and B. Convergent genes shape budding yeast pericentromeres Marston lab paper featured in Nature. High density of unrepaired genomic ribonucleotides leads to Topoisomerase 1-mediated severe growth defects in absence of ribonucleotide reductase Tollervey lab paper featured in Nucleic Acids Research. Structural basis for centromere maintenance by Drosophila CENP-A chaperone CAL1 Jeyaprakash lab paper featured in EMBO Journal. PALB2 Chromatin Recruitment Restores Homologous Recombination in BRCA1-deficient Cells Depleted of 53BP1 Wilson lab paper featured in Nature communications. Hap2-Ino80-facilitated transcription promotes de novo establishment of CENP-A chromatin Allshire lab paper featured in Genes and Development. This article was published on 2024-06-17
