Herpes simplex virus ICP27 protein directly interacts with the nuclear pore complex through Nup62, inhibiting host nucleocytoplasmic transport pathways

Schirmer lab paper featured in Journal of Biological Chemistry.

Image
Image from Schirmer paper, Journal of Biological Chemistry 2012

Authors

Malik P, Tabarraei A, Kehlenbach RH, Korfali N, Iwasawa R, Graham SV, Schirmer EC.

Summary

Herpesviruses block host cell transport into the nucleus through herpes-encoded ICP27 binding to nuclear pore complex protein Nup62. The image shows ICP27 preventing nuclear translocation of a GFP reporter construct.

PMID:   22334672

Related links

Doi

Journal Link