Genome-wide distribution of RNA-DNA hybrids identifies RNase H targets in tRNA genes, retrotransposons and mitochondria

Tollervey lab paper featured in PLoS Genetics.

Image
Image from Tollervey paper, PLoS Genetics 2014
Artwork: “R-loops form in the dark” by  Hratch Arbach

Authors

El Hage, A., Webb, S., Kerr, A. and Tollervey D.

Summary

The foreground shows the transcribing RNA polymerase with an R-loop forming between the nascent transcript and the DNA. In the Ty1 pre-integration complex two integrase molecules (colored in pink) target nucleosomes upstream of tRNA genes. Three left-handed arrows indicate potential interactions between the R-loop and Ty1 pre-integration complex.

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