Tollervey lab paper featured in Molecular and Cellular Biology. Image Figure: Two aspects of ncRNA are likely to contribute to rapid degradation: (Left) Some exosome cofactors bind nascent RNA, \"pretargeting\" it for degradation as soon as the 3' end is released from the transcribing polymerase; (Right) Multiple, partially redundant cofactors target the ncRNA for degradation. Authors Milligan L, Decourty L, Saveanu C, Rappsilber J, Ceulemans H, Jacquier A, Tollervey D. Molecular and Cellular Biology 28(17): 5446-5457, September 2008 Summary The exosome complex depends on different cofactors for in vivo RNA degradation activity. In an attempt to identify novel exosome cofactors, the Tollervey lab performed a genome-wide screen for synthetic lethal interactions with nuclear exosome cofactors Rrp47 or Air1. This identified Mpp6, a novel exosome cofactor involved in RNA surveillance of pre-rRNA and pre-mRNA. Mpp6 together with other exosome cofactors also targets noncoding RNAs for degradation. Related links Journal link Copyright © 2008, American Society for Microbiology. All Rights Reserved. This article was published on 2024-06-17
