Programme project supervisors and their research interests. All iCM PhD projects are collaborative between two supervisors who have complementary expertise: one in cell mechanisms and one in quantitative skills. The definition of ‘quantitative skills’ is broad and includes Computational Data Sciences, Mathematics, Biophysics, Structural Biology, Chemical Biology and Biomaterials. By integrating these different areas into collaborative cross-disciplinary projects we will break new ground in understanding cellular mechanisms pertinent to the biomedical arena. The following supervisors are affiliated with the programme. Each year supervisors are asked to establish partnerships to develop exciting inter-disciplinary projects. Therefore, the list of projects and supervisor pairings offered to each cohort will change annually. 2023 - 2024 iCM Project Supervisors Name Topic Cei Abreu-Goodger RNA Computational Genomics Ian Adams Mammalian Meiosis Neha Agrwall Systems physiology, obesity and associated disorders, neuro-metabolism, adipose biology, Drosophila disease models Bungo Akiyoshi Evolutionary cell biology of chromosome segregation Robin Allshire Chromatin-based epigenetic inheritance: Specialised chromatin states Jeyprakash Arulanandam Structural Biology & Cell Division Jelena Baranovic function and pharmacology of synaptic ion channels, synaptic architecture Paul Barlow The complement system and disease Elizabeth Bayne Genome Regulation & Epigenetics Wendy Brickmore Genome regulation and organisation Clare Blackburn Synthetic thymus biology (or, Tissue stem cells & reprogramming) Guillaune Blin Using human ESCs and microfabrication approaches to understand how embryonic cells integrate physical and biochemical cues to form patterns of cell fates. Chris Brackley Physics of the genome: How the spatial organisation of the genome plays a role in its function Sara Buonomo DNA replication/nuclear organisation Karl Burgess Mass spectrometry, Metabolomics and proteomics Dominic Campopiano Sphingolipid biosynthesis Ian Chambers Pluripotent Stem Cell Biology Dhanya Cheerambathur Neuronal Cytoskeletal Mechanisms Atlanta Cook Structural RNA Biology Owen Davies Mammalian Meiosis Tom Deegan Molecular mechanisms of chromosome replication . Katherine Dunn Bioengineering Alistair Elfick Mammalian synthetic biology; optical spectroscopy; biometrology; bioengineering Jose-Luis Garcia Perez Mammalian Retrotransposons Nick Gilbert Chromatin Structure Andrew Goryachev Centromere organization Sander Granneman RNA Systems Biology Ramon Grima Stochastic modeling of biosystems Kevin Hardwick Mitosis in fungal pathogens Matt Horrocks Single molecule Biophysics Alison Hulme Synthetic methodology development and chemical biology in biology and medicine Andrew Jackson Microcephaly, genome stability, inflammation and growth Grzegorz Kudla RNA synthetic biology Georg Kustatscher Proteome systems biology Nadanai Laohakunakorn Synthetic biology Schumacher Linus We use mathematical models and computational simulations to predict tissue behaviour from the interactions of cells Sally Lowell Pluripotent stem cell differentiation Cait MacPhee Biomolecular self-assembly Sveta Makovets Telomeres and genome stability Davide Marenduzzo DNA and chromosome modelling Joseph Marsh Structural bioinformatics Adele Marston Mitosis and Meiosis Gavin MeLaugh Microbial systems/biophysics of environmentally relevant microbes Filippo Menolascina Modeling endogenous and synthetic biomolecular networks in-silico and in-vivo/in-vitro experiments in microfluidics Davide Michieletto DNA topology Dónal O'Carroll RNA and the germline Hiro Ohkura Meiotic spindle and chromosomes in oocytes Diego Oyarzun Systems & Synthetic Biology Teuta Pilitoza Biological physics: bacterial electrophysiology Chris Ponting Computational and experimental genomics, biophysics, noncoding RNAs, evolution, gene regulation, and biology of single cells Wilson Poon Physics of Active particles Lynne Regan Illuminating and modifying the proteome Susan Rosser Synthetic Biology Ken Sawin Cell polarity, stress and the cytoskeleton Eric Schirmer Nuclear membrane functions Chris Sibley RNA biology and molecular neuroscience Abdenour Soufi Chromatin structure and cellular identity Duncan Sproul Interdisciplinary approaches to understand the role of epigenetic dysfunction in human disease Giovanni Stracquadanio Cancer genetics, genomics and transcriptomics; protein engineering; synthetic genomics; lysosomal storage diseases Matthew Swaffer Effects of cell size on gene expression, biosynthesis and cell function Peter Swain Cellular decision-making David Tollervey RNA-protein interactions Edward Wallace RNA systems biology in fungi Andrea Weisse Computational systems biology, antimicrobial resistance, disease transmission Julie Welburn Mechanistic cell Biology of cell division and cytoskeleton Val Wilson Early embryo development Marcus Wilson Chemical and structural biology: Mechanisms of Epigenetic Marks Chris Wood Protein design This article was published on 2024-06-17
