Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia

O'Carroll lab paper featured in Cell Stem Cell.

Image from O'Carroll paper, Cell Stem Cell 2019

Authors

Paris, J., Morgan, M., Campos, J., Gregory, R.I., O’Carroll, D., Kranc, K.R.

Summary

  • YTHDF2 is highly expressed across human AML and is essential for leukemia initiation
  • YTHDF2 shortens the half-life of m6A-modified transcripts in AML
  • Loss of YTHDF2 expands HSCs but does not derail hematopoiesis
  • YTHDF2 protects AML cells from apoptosis by downregulating TNFR2

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