The C-terminal region of MCAK controls its activity and structure through a major conformational switch

Welburn lab paper featured in eLife.

Image
Image from Welburn paper, eLife 2015

Authors

Talapatra S., Harker B., Welburn JPI.

Summary

Structural analysis of the kinesin-13 MCAK bound to its C-terminal tail reveals the molecular basis for the conformation of kinesin-13 in solution and the mechanism that triggers long-range conformational changes upon microtubule binding.

Related links

Journal Link