Borealin-nucleosome interaction secures chromosome association of the chromosomal passenger complex

Jeyaprakash lab paper featured in the Journal of Cell Biology.

Image
Image from Jeyaprakash paper, Journal of Cell Biology 2019

Authors

Abad, M.A., Ruppert, J.G., Buzuk, L., Wear, M., Zou, J., Webb, K.M., Kelly, D.A., Voigt, P., Rappsilber, J., William C. Earnshaw, W.C., Jeyaprakash, A.A.

Summary

Abad et al. report that the chromosomal passenger complex (CPC), an essential regulator of error-free chromosome segregation, is targeted to chromosomes via Borealin-mediated direct interaction with nucleosomes. This is critical for subsequent histone modification–dependent centromere enrichment and function of the CPC during metaphase.

Related links

Journal Link

JP Arulanandam Lab Website

DOI