Shugoshin biases chromosomes for biorientation through condensin recruitment to the pericentromere

Marston lab paper featured in eLife.

Image
Image from Marston paper elife 2014

Authors

Kitty F. Verzijlbergen, Olga O. Nerusheva, David Kelly, Alastair Kerr, Dean Clift, Flavia de Lima Alves, Juri Rappsilber and Adele L. Marston

Summary

During cell division the chromosomes line up in a way that increases the chances that the daughter cells will each inherit one copy of each chromosome after cell division.  This study shows that proteins known as shugoshins assemble a "hub" on a region of the DNA called the pericentromere that monitors the lining up of chromosome for accurate cell division.

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