Beggs lab paper featured in the Journal of Cell Science. Image Efficient localization of Lsm1p to P-bodies depends on the Q/N rich C-terminus of Lsm4. Compare GFP-Lsm1 bright spots (P-bodies) in LSM4 wild type yeast (left) versus lsm4DC (a deletion of the C-terminus, right) Authors Reijns MA, Alexander RD, Spiller MP, Beggs JD. Journal of Cell Science 121 (15): 2463-2472 Summary P-bodies are cytoplasmic mRNA-processing foci containing a variety of RNA-degradation factors. In this study the Beggs lab shows that efficient accumulation of RNA-degradation factors in P-bodies is promoted by regions rich in glutamine and/or asparagine (Q/N rich regions). The presence of these regions in other P-body components suggests a possible general role in localization and assembly of P-bodies. Related links Journal link This article was published on 2024-06-17
