Pervasive coexpression of spatially proximal genes is buffered at the protein level

Rappsilber lab paper featured in Molecular Systems Biology.

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Image from Rappsilber paper, Molecular Systems Biology 2017

Authors

Kustatscher, G., Grabowski, P., Rappsilber, J.

Summary

Housekeeping genes are clustered in the human genome, which minimizes stochastic silencing but leads to partial coexpression of thousands of functionally unrelated genes. This non‐functional mRNA coexpression is buffered at the protein level.

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