The kinetochore prevents centromere-proximal crossover recombination during meiosis

Marston lab paper featured in eLife.

Image
Image from Marston paper, elife 2015

Authors

Vincenten N, Kuhl LM, Lam I, Oke A, Kerr AR, Hochwagen A, Fung J, Keeney S, Vader G, Marston AL.

Summary

This study shows that the kinetochore and the cohesin-rich pericentromere spatially control meiotic recombination thereby providing the first molecular evidence for the long-observed phenomenon of crossover suppression near centromeres.

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