A splicing-dependent transcriptional checkpoint associated with pre-spliceosome formation

Beggs lab paper featured in Molecular Cell.

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Image from Beggs Mol Cell 2014

Authors

Keerthi T. Chathoth, J. David Barrass, Shaun Webb and Jean D. Beggs

Summary

Transcriptional elongation is inhibited when cotranscriptional pre-spliceosome formation is blocked. The defect is characterised by RNA polymerase with hyperphosphorylated Serine 5 (red P) on the CTD accumulating on introns.

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