Interspecies conservation of organisation and function between nonhomologous regional centromeres

Allshire lab paper featured in Nature Communications.

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Image from Allshire paper, Nature Communications 2019

Authors

Pin Tong, Pidoux, A.L., Toda, N.R.T., Ard, R., Harald Berger, H., Manu Shukla, M., Torres-Garcia, J., Carolin A. Müller, C.A., Nieduszynski, C.A. & Allshire, R.C.

Summary

Although the centromere-specific histone CENP-A usually assembles on specific genomic sequences, centromeric DNA is not conserved. Here the Allshire Lab characterise the genome and centromeres of related fission yeasts and provide evidence that Schizosaccharomyces centromere DNA possesses intrinsic conserved properties that promote assembly of CENP-A chromatin.

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