Earnshaw lab paper featured in EMBO Journal. Image Authors Bergmann JH, Rodríguez MG, Martins NM, Kimura H, Kelly DA, Masumoto H, Larionov V, Jansen LE, Earnshaw WC. Summary Accurate chromosome segregation is essential to avoid aneuploidy, a condition that leads to birth defects and cancer. We have been able to specifically remove a single histone modification from the kinetochore of a synthetic human chromosome that segregates like native chromosomes. This blocks the ability of the kinetochore to duplicate itself after cell division. This study begins to reveal the links between chromatin modifications and RNA transcription in the maintenance of the chromosome segregation machinery. Related links Doi Copyright 2011 European Molecular Biology Organization | Some Rights Reserved 0261-4189/11 Journal Link Comment on paper This article was published on 2024-06-17
