Aurora B kinase disrupts the extended conformation of lattice-bound Kinesin-13 MCAK

Welburn lab paper featured in Journal of Cell Science.

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Image from Welburn paper Journal of Cell Science 2019

Authors

McHugh, T., Zou, J., Volkov, V., Bertin, A., Rappsilber, J., Dogterom, M., Welburn, J.P.I.

Summary

The kinesin-13 MCAK has a compact conformation in solution but is extended when bound to microtubules. Aurora B AQ23 phosphorylation of MCAK inhibits depolymerase activity by disrupting its extended conformation.

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