Schirmer lab paper featured in Molecular Cell Proteomics. Image Novel new blood nuclear envelope transmembrane proteins. Authors Korfali N, Wilkie GS, Swanson SK, Srsen V, Batrakou DG, Fairley EA, Malik P, Zuleger N, Goncharevich A, de Las Heras J, Kelly DA, Kerr AR, Florens L, Schirmer EC. Summary Investigation of the human blood leukocyte nuclear envelope proteome has revealed many novel nuclear envelope transmembrane proteins not identified in previous proteomic analyses of the nuclear envelope. Both resting and PHA-stimulated leukocytes were analysed to identify nuclear envelope transmembrane proteins involved in tethering chromatin to the nuclear periphery because these two conditions yield major differences in the distribution of peripheral heterochromatin. Indeed screening some of the novel proteins identified for their ability to promote chromatin condensation or to recruit a particular locus to the periphery revealed several with these separate functions. Related links Journal Link This article was published on 2024-06-17
