Schirmer lab paper featured in PLoS One. Image Authors Korfali N, Srsen V, Waterfall M, Batrakou DG, Pekovic V, Hutchison CJ, Schirmer EC. Summary Screening many novel nuclear envelope transmembrane proteins (NETs) identified in their previous proteomic studies for cell cycle defects, the Schirmer lab identified 8 novel proteins that contribute to cell cycle regulation. This indicates a much more significant role in cell cycle regulation than previously thought for the nuclear envelope. Further study of one of these NETs revealed that it affects p38MAP kinase pathways in order to promote cell cycle withdrawal. The figure shows in panel A the FACS G1 vs G2/M DNA profiles for cells expressing a NET with no effect (C14orf1) or one with an effect (Tmem209). The ratio of G2/M to G1 phase cells is plotted for a few controls and several NETs with effects in panel B. Related links Doi Journal Link This article was published on 2024-06-17
