14-3-3 regulation of Ncd reveals a new mechanism for targeting proteins to the spindle in oocytes

Ohkura lab paper featured in the Journal of Cell Biology.

Image
Image from Ohkura paper Journal of Cell Biology 2017

Authors

Beaven, R., Nunes Bastos, R., Spanos, C., Romé, P., Cullen, C.F., Rappsilber, J., Giet, R., Goshima, G. and Ohkura, H.

Summary

14-3-3 interacts with the kinesin-14 Ncd and prevents it from binding microtubules. Aurora B provides a spatial cue that releases Ncd from 14-3-3 around chromosomes, allowing Ncd to selectively bind the spindle microtubules in the large volume of oocytes.

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