Mapping the human miRNA interactome by CLASH reveals frequent non-canonical binding

Tollervey lab paper featured in Cell.

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Image from Tollervey paper, Cell 2013

Authors

Helwak, A., Kudla, G., Dudnakova, T., Tollervey, D.

Summary

miRNAs play many important regulatory roles, but their targets have been difficult to identify systematically. The Tollervey group have used a new experimental approach, termed CLASH, to directly identify more than 18,000 interaction sites between miRNA and mRNA molecules in human cells. Their transciptome-wide dataset reveals different modes of interactions, and uncovers the diversity of in vivo targets for miRNAs.

 PMID: 23636380

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