Ska3 Ensures Timely Mitotic Progression by Interacting Directly With Microtubules and Ska1 Microtubule Binding Domain

Jeyaprakash lab paper featured in Scientific Reports.

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Image from Jeyaprakash paper Scientific Reports 2016

Authors

Abad, M.A., Zou, J, Medina-Pritchard, B, Nigg, E.A., Rappsilber, J, Santamaria, A. Jeyaprakash, A.A.

Summary

In this work, we show that the Ska3 C-terminal domain modulates the microtubule binding activity of the Ska complex by directly interacting with microtubules and Ska1 microtubule binding domain.  This modulatory role of Ska3 is required for timely onset of anaphase.

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