Tollervey lab paper featured in EMBO Journal. Image Authors Wlotzka W, Kudla G, Granneman S, Tollervey D. Summary (A) The Nrd1-Nab3 heterodimer was previously known to interact with the mRNA cap-binding complex (CBC) and with RNA Polymerase II. Nrd1-Nab3 initiate transcription termination following recognition of consensus binding sites, which are present in genes encoding small nuclear and small nucleolar RNAs and a variety of long ncRNAs (CUTs and SUTs). They subsequently recruit TRAMP and exosome complexes for oligoadenylation and degradation or processing of the target RNA. (B) Nrd1-Nab3 are now shown to also interact post transcriptionally with aberrant Pol III transcripts, including precursors to tRNA and the RNA component of RNase P, recognizing consensus binding motifs and/or structural abnormalities in the RNA. They subsequently recruit TRAMP and exosome complexes for oligoadenylation and degradation. Related links Journal Link This article was published on 2024-06-17
