Marston lab paper featured in Genes & Development. Image Authors Olga O. Nerusheva, Stefan Galander, Josefin Fernius, David Kelly and Adele L. Marston Summary This study addresses how tension between chromosomes signals their proper alignment for segregation during cell division. Marston and colleagues show that budding yeast shugoshin dissociates from the pericentromere reversibly in response to tension. The antagonistic activities of the kinetochore-associated Bub1 kinase and the shugoshin-bound phosphatase PP2A-Rts1 underlie a tension-dependent circuitry that enables shugoshin removal upon sister kinetochore biorientation. The findings expose shugoshin as the pivotal sensor of tension between sister kinetochores. Related links Journal Link This article was published on 2024-06-17
