Earnshaw lab paper featured in the Journal of Cell Biology. Image Authors Xu Z, Ogawa H, Vagnarelli P, Bergmann JH, Hudson DF, Ruchaud S, Fukagawa T, Earnshaw WC, Samejima K. Summary The striking and dynamic localization of the chromosomal passenger complex (CPC) during mitosis is essential for its diverse functions. Interactions of the INCENP N-terminus with Borealin and Survivin direct centromere targeting of the complex. Little is known about how association of the INCENP C-terminus with Aurora B through its highly conserved IN-Box influences CPC targeting and function during mitosis in vivo. In the current study, which uses a conditional knockout of INCENP in DT40 cells, the Earnshaw group provides further insights into CPC formation and demonstrates that CPC transfer from the inner centromeres to the central spindle during anaphase onset is directly regulated by an intrinsic mechanism within the CPC itself. INCENP modulates Aurora B kinase activity in vivo and this in turn correlates with different functional states of the CPC. Related links DOI Journal link This article was published on 2024-06-17
