3D-CLEM Reveals that a Major Portion of Mitotic Chromosomes Is Not Chromatin

Earnshaw lab paper featured in Molecular Cell.

Image
Image from Earnshaw Molecular Cell paper 2016

Authors

Booth, D.G., Beckett, A.J., Molina, O., Samejima, I., Masumoto, H., Kouprina, N., Larionov, V., Prior, I.A., and Earnshaw, W.C.

Summary

3-dimentional correlative light and electron microscopy reveals that ≥ 33% of mitotic chromosomes is not chromatin, but is instead a peripheral layer that is largely derived from nucleoli. This mysterious layer is very little studied, but experiments suggest that it may have important roles in re-establishing the internal organisation of the interphase nucleus after cell division.

Related links

Journal Link