Shugoshin prevents cohesin cleavage by PP2ACdc55-dependent inhibition of separase.

Marston lab paper featured in Genes and Development.

Authors

Image
Image from Marston paper, Genes and Development 2009

Dean Clift, Farid Bizzari and Adele L. Marston

Genes and Development, 23: 766-780. March 2009-05-04.

Summary

The Marston lab investigated the mechanism by which the protector protein Shugoshin counteracts cohesin cleavage in budding yeast. This work identified a novel pathway for separase inhibition.

Related links

Journal link