Centromere transcription allows CENP-A to transit from chromatin association to stable incorporation

Heun lab paper featured in the Journal of Cell Biology.

Image
Image from Heun paper, Journal of Cell Biology 2018

Authors

Bobkov, G.O.M., Gilbert, N., Heun, P.

Summary

Transcription is important for the loading of the epigenetic centromere mark CENP-A, yet its role remains unclear. In this study, we report that transcription-mediated chromatin remodelling enables the transition of centromeric CENP-A from chromatin association to full nucleosome incorporation.

Related links

Journal Link

Heun Lab website