The cell-wide web coordinates cellular processes by directing site-specific Ca2+ flux across cytoplasmic nanocourses

Schirmer lab paper featured in Nature Communications.

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Image from Schirmer paper Nature Communications 2019

Authors

Duan, J., Navarro-Dorado, J., Clark, J.H., Kinnear, N,P., Meinke, P., Schirmer, E.C., Evans, A.M.

Nature Communications (2019) 10(1):2299

Summary

Smooth muscle cells have massive nuclear invaginations that co-localize with the frequently "poised" epigenetic mark H3K9me2 and these invaginations are lost when cells are cultured (top images). These invaginations also support Ca2+ signaling to the nucleus that may play roles in gene regulation (bottom image).

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