Schirmer lab paper featured in Cells. Image Authors Saiz-Ros, N., Czapiewski, R., Epifano, I., Stevenson, A., Swanson, S.K., Dixon, C.R., Zamora, D.B., McElwee, M., Vijayakrishnan, S., Richardson, C.A., Dong, L,, Kelly, D.A., Pytowski, L., Goldberg, M.W., Florens, L., Graham, S.V., Schirmer, E.C.. Summary The least mechanistically understood aspect of herpes simplex virus infection is how virus particles — too large to go through the nuclear pore complexes — escape the nucleus. Saiz-Ros and colleagues show that host cell vesicle fusion protein VAPB is important for this process with virus particles accumulating in the nucleus upon VAPB knockdown (left) and infectious virus titers dropping upon VAPB knockdown >10-fold (right). Related links Journal Link DOI This article was published on 2024-06-17
