Reductional meiosis I chromosome segregation is established by coordination of key meiotic kinases

Marston lab paper featured in Developmental Cell.

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Image from Marston paper, Developmental Cell 2019

Authors

Galander, S., Barton, R.E., Borek, W.E., Spanos, C., Kelly, D.A., Robertson, D., Rappsilber, J. and Marston, A.L.

Summary

Uniquely during meiosis I, homologs, rather than sister chromatids, are segregated. Galander et al. show that the meiosis I-specific Spo13 protein prevents sister chromatid segregation by controlling the effects of multiple kinases to both enforce sister kinetochore co-orientation and prevent premature loss of cohesion.

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