Ad Hoc Seminar - Professor Joao Matos, University of Vienna, Austria Joao Matos Professor of Cell and Developmental Biology at the University of Vienna.The seminar is open to all.Chromosome context and feedback mechanisms in meiotic crossover control.AbstractMeiotic crossovers emerge from a complex interplay between DNA recombination intermediates and the specialized chromosome structures in which they form. Our work suggests that this relationship is reciprocal: chromosome organization controls the fate of recombination intermediates, while the intermediates themselves help establish and maintain a chromosome environment that promotes their maturation into crossovers. I will discuss how feedback between ZMM proteins and Holliday junctions contributes to crossover assurance, and present new work revealing how chromatin organization regulates the activity of the crossover resolvase MutLγ. Finally, I will explore how the chromatin remodeler CHD1 contributes to this regulatory environment. Together, our findings point to chromosome and chromatin organization as active determinants of crossover fate during meiosis. Nov 19 2026 10:00am - 11:00am Ad Hoc Seminar - Professor Joao Matos, University of Vienna, Austria Chromosome context and feedback mechanisms in meiotic crossover control. Room 7.20 Michael Swann Building, King's Buildings This article was published on Friday 6 November 2026
Ad Hoc Seminar - Professor Joao Matos, University of Vienna, Austria Joao Matos Professor of Cell and Developmental Biology at the University of Vienna.The seminar is open to all.Chromosome context and feedback mechanisms in meiotic crossover control.AbstractMeiotic crossovers emerge from a complex interplay between DNA recombination intermediates and the specialized chromosome structures in which they form. Our work suggests that this relationship is reciprocal: chromosome organization controls the fate of recombination intermediates, while the intermediates themselves help establish and maintain a chromosome environment that promotes their maturation into crossovers. I will discuss how feedback between ZMM proteins and Holliday junctions contributes to crossover assurance, and present new work revealing how chromatin organization regulates the activity of the crossover resolvase MutLγ. Finally, I will explore how the chromatin remodeler CHD1 contributes to this regulatory environment. Together, our findings point to chromosome and chromatin organization as active determinants of crossover fate during meiosis. Nov 19 2026 10:00am - 11:00am Ad Hoc Seminar - Professor Joao Matos, University of Vienna, Austria Chromosome context and feedback mechanisms in meiotic crossover control. Room 7.20 Michael Swann Building, King's Buildings This article was published on Friday 6 November 2026
Nov 19 2026 10:00am - 11:00am Ad Hoc Seminar - Professor Joao Matos, University of Vienna, Austria Chromosome context and feedback mechanisms in meiotic crossover control.
