Bringing together intellectual and technical expertise to illuminate the most significant hidden areas of Cell Biology. Our platform focuses on the intractable and unexplored areas of Cell biology, which we term the Hidden Cell. Technical and cultural limitations have resulted in knowledge barriers preventing our full understanding of the complexity and scale of sub-cellular processes. To overcome these barriers the DRP-HCB brings together cross-disciplinary scientists who will together compile a critical mass of molecular characterisation and insights to make these understudied areas accessible to the research and medical communities. The DRP-HCB aims to: Re-focus the cell biology research landscape towards major unsolved challenges, Provide scientific insights that drive new hypotheses in previously unforeseen areas, and Create a paradigm for broad data and insight distribution to ignite and advance scientific enquiry. Image Realising our Vision The DRP-HCB is focused on three broad areas of hidden cell biology Proteome Characterisation – unchartered proteomes Atom to Cell – disconnect between atomic structures and cellular scales Rare Events – undetected rare and stochastic events To overcome these barriers DRP-HCB has established five Technology Cores: Proteomics Core Structural Biology Core (formerly Cryo-EM and crystallisation facility) Light Microscopy Core (formerly COIL) Bioinformatics Core Data Integration Core (from December 2024). DRP-HCB is also affiliated with facilities that are operating independently including the Edinburgh Genome Foundry (EGF), Edinburgh protein production facility (EPPF) and the Single Cell Sequencing Facility. Delivering our vision We will disrupt cultural barriers to interdisciplinary working, Overcome technical barriers, and Establish new research infrastructure models fit for future discovery science This article was published on 2024-06-17
