Visualising the molecular sociology of protein complexes Abstract: to followHost: Alistair McCormickAbstract: Biological membranes, mostly made up of lipids and proteins, separate different cell compartments and serve as a general permeation barrier and, at the same time, perform essential roles, including the transport of small metabolites, ions, lipids and proteins. Perturbations of membranes, mutations and misassembly of membrane proteins are often associated with cell death, disease and developmental defects and, therefore, are of critical interest in pharmaceutical discovery, as more than 60% of drug targets are located on the cell surface or in cellular membranes. Any attempts to harness or control the activities within and across membranes require a comprehensive understanding of the associated molecular mechanisms. In our laboratory, we use experimental methods, including native mass spectrometry (MS), cryo-electron microscopy, H/D exchange MS as well as computational approaches to elucidate the evolutionarily conserved mechanisms of membrane biogenesis and transport in pathogenic Gram-negative bacteria and endosymbiotic organelles like chloroplasts. In this talk, I will present our latest findings on several membrane complexes. May 15 2025 09.30 - 10.30 Visualising the molecular sociology of protein complexes Jani R Bolla, Department of Biology, University of Oxford Seminar room 1.08, C.H. Waddington Building, Max born Crescent, Kings Buildings Campus Bolla Group
Visualising the molecular sociology of protein complexes Abstract: to followHost: Alistair McCormickAbstract: Biological membranes, mostly made up of lipids and proteins, separate different cell compartments and serve as a general permeation barrier and, at the same time, perform essential roles, including the transport of small metabolites, ions, lipids and proteins. Perturbations of membranes, mutations and misassembly of membrane proteins are often associated with cell death, disease and developmental defects and, therefore, are of critical interest in pharmaceutical discovery, as more than 60% of drug targets are located on the cell surface or in cellular membranes. Any attempts to harness or control the activities within and across membranes require a comprehensive understanding of the associated molecular mechanisms. In our laboratory, we use experimental methods, including native mass spectrometry (MS), cryo-electron microscopy, H/D exchange MS as well as computational approaches to elucidate the evolutionarily conserved mechanisms of membrane biogenesis and transport in pathogenic Gram-negative bacteria and endosymbiotic organelles like chloroplasts. In this talk, I will present our latest findings on several membrane complexes. May 15 2025 09.30 - 10.30 Visualising the molecular sociology of protein complexes Jani R Bolla, Department of Biology, University of Oxford Seminar room 1.08, C.H. Waddington Building, Max born Crescent, Kings Buildings Campus Bolla Group
May 15 2025 09.30 - 10.30 Visualising the molecular sociology of protein complexes Jani R Bolla, Department of Biology, University of Oxford
