Origins and consequences of partitioning in bacteria My lab is working on a broad range of topics with a focus on partitioning in bacteria. Binary fission of rod-shaped bacteria results in virtually identical sibling cells, which consist of the same genetic makeup. Despite of being extremely similar, such clonal sibling cells can differ from each other phenotypically and consequently display distinct behaviors. Unequal or biased partitioning of cellular constituents at cell division is one non-exclusive, yet little understood mechanism that can generate such phenotypic heterogeneity. I will show how directional inheritance of cell structures leads to non-random variability in basic traits such as cell size or live span. My recent work focuses on partitioning of multi-drug efflux pumps in Escherichia coli, which are large trans-membrane- and trans-envelope protein structures. Here, biased partitioning results in different degrees of antibiotic tolerance in individual cell lineages. Current work investigates a potential source of biased partitioning of membrane proteins by studying the dynamics and localization of translating mRNA molecules at the subcellular level. Group website Host: Prof Rosalind Allen Jun 03 2021 12.00 - 13.00 Origins and consequences of partitioning in bacteria Seminar by Dr Tobias Bergmiller, University of Exeter Online - Blackboard Collaborate Platform
Origins and consequences of partitioning in bacteria My lab is working on a broad range of topics with a focus on partitioning in bacteria. Binary fission of rod-shaped bacteria results in virtually identical sibling cells, which consist of the same genetic makeup. Despite of being extremely similar, such clonal sibling cells can differ from each other phenotypically and consequently display distinct behaviors. Unequal or biased partitioning of cellular constituents at cell division is one non-exclusive, yet little understood mechanism that can generate such phenotypic heterogeneity. I will show how directional inheritance of cell structures leads to non-random variability in basic traits such as cell size or live span. My recent work focuses on partitioning of multi-drug efflux pumps in Escherichia coli, which are large trans-membrane- and trans-envelope protein structures. Here, biased partitioning results in different degrees of antibiotic tolerance in individual cell lineages. Current work investigates a potential source of biased partitioning of membrane proteins by studying the dynamics and localization of translating mRNA molecules at the subcellular level. Group website Host: Prof Rosalind Allen Jun 03 2021 12.00 - 13.00 Origins and consequences of partitioning in bacteria Seminar by Dr Tobias Bergmiller, University of Exeter Online - Blackboard Collaborate Platform
Jun 03 2021 12.00 - 13.00 Origins and consequences of partitioning in bacteria Seminar by Dr Tobias Bergmiller, University of Exeter
