Decoding the genome

Research groups addressing how gene expression, epigenetics and proteoforms effect biological processes and disease.

Epigenetic mechanisms mediating fungicide and antifungal resistance.

diagram of tunable degradation of transcription factors

Understanding gene regulation from the dark genome.

stained cells

Mechanisms by which chromatin proteins interpret genomic signals to change or stabilise cell states.

Structural biology of macromolecular complexes in RNA metabolism.

CRAC RBPome figure

The role of non-coding RNAs and RNA-binding proteins in regulating gene expression during adaptive responses in microbes.

Gene Regulation in Human Craniofacial Development

Gene regulation in human craniofacial development and disease.

embryonic defects caused by unbalanced immune responses

RNA & antiviral immunity.

structure diagram of proteins binding DNA

How genetic variation in protein-coding genes leads to human disease.

Mechanisms of germline integrity and fitness.

Glioblastoma cells

Transcriptional control of cell fate in stem cells and cancer stem cells.

genome organisation in adipogenesis and lipodystrophy

Tissue-specific nuclear envelope organization in genome and nuclear size regulation: roles in inherited metabolic disorders, muscular dystrophy, and virus infection.

microRNA degradation in the Cerebellum

Regulatory non-coding RNA.

Protein degradation on plants

Epiproteome and the immune response in plants.