The Team

Who are in the MacDonald Lab

Andrew MacDonald

Principal investigator

Andrew completed his PhD studying immunity to parasitic worms (helminths) at the Institute of Immunology and Infection Research (IIIR), University of Edinburgh, in 1998. After several years in the U.S., first at Cornell University and then at the University of Pennsylvania, he returned to the UK in 2002 to the University of Edinburgh where he established his lab through successive MRC Career Development and Senior Fellowships at IIIR. In January 2013 he took up the position of Professor of Immunology at the University of Manchester at the Manchester Collaborative Centre for Inflammation Research, which was established in 2012 to address current priorities in inflammatory disease in an innovative collaboration between the University of Manchester, AstraZeneka and GSK. In 2024, he returned to IIIR and the University of Edinburgh to take up the position of Professor of Cellular Immunology. His research addresses some outstanding fundamental questions about activation and modulation of innate and adaptive immunity, with a particular emphasis on Type 2 inflammation, which is a defining feature of infection with helminths, as well as being responsible for widespread suffering in allergies.

Email: andrew.macdonald@ed.ac.uk

Bluesky: profandrewmac.bsky.social

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Anna Andrusaite

Postdoctoral Research Associate

Anna is a postdoctoral researcher in the MacDonald Lab with a particular interest in the gut immune system. She focuses on intestinal dendritic cells, which play a central role in maintaining immune balance. These cells integrate environmental signals and determine the type of immune response required—for example, promoting tolerance to harmless antigens such as food and commensal microbes, while mounting protective responses against harmful pathogens. However, the molecular mechanisms that enable dendritic cells to perform this dual function remain incompletely understood. In her research, Anna uses parasite infection models to “mine” evolutionarily developed parasite immunomodulatory strategies, aiming to uncover how specific molecules or signalling pathways influence dendritic cell function.

Email: Anna.Andrusaite@ed.ac.uk

Bluesky: annaandrusaite.bsky.social

Vivien Shek

Postdoctoral Research Associate

Vivien completed her PhD in Immunoparasitology at the University of Dundee, where she became fascinated by how parasites can influence the immune system. She now works in the MacDonald Lab, studying how infection with Schistosoma mansoni affects immune responses in the gut. Her research focuses on how immune cells interact with epithelial and stromal cells. By understanding how parasites shape these responses, Vivien hopes to uncover new ways to treat inflammatory diseases. When she’s not in the lab talking about worms, she enjoys bouldering and baking.

Email: vshek@ed.ac.uk 

Bluesky: vshek.bsky.social

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Hao Wang

Lab Manager

Hao oversees daily laboratory operations, Health & Safety, and sustainability initiatives, while supporting research on immune mechanisms in helminth infection. She maintains Schisto-infected snails that produce cercariae used in infection and immunology studies. Hao is passionate about lab management, technical development, and fostering an efficient, sustainable research environment. Outside the lab, she enjoys cycling, running, traveling, and trying different foods.

 

Email: hao.wang@ed.ac.uk

Bluesky: haohao25.bsky.social

Natalia Wasowska

PhD Student

Natalia started her PhD in February 2025 and is passionate about investigating the protective immune responses against Schistosoma mansoni infection in the lung. Natalia obtained her BSc in Biotechnology at the University of Warsaw, Poland and her MSc at the Wageningen University, the Netherlands. She had the great opportunity to carry out her thesis project at the University of Glasgow researching helminth immunomodulation and afterwards worked at the Leiden University Medical Center looking into the effect of SCFAs on respiratory viral infections in human in vitro models. Natalia is hoping to combine her interest in parasitology and the lung environment in her PhD project. In her free time you can find her queuing for the most buttery pastries all over Lothian. 

 

Email: n.l.wasowska@sms.ed.ac.uk

Bluesky: nwasowska.bsky.social

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