Publications

Davey, S.D., Forde-Thomas, J.E., Hulme, B.J., Lees, K., Costain, A.H., Evans, M., Rinaldi, G., Frame, L., Stojanovski, L., Simeons, F.R.C., Tavendale, A., MacLeod, A.K., Pichon, R., Lee, Y.H., Polak, O., Chalmers, I.W., Dankwa, B., Odhiambo, B.K., Guimaraes, V.H., Hegarty, M., Swain, M.T., Aubrey, W., Caldwell, N., MacDonald, A.S., Gilbert, I.H., Baragaña, B., Read, K.D., Hoffmann, K.F., 2026. Use of a cytochrome P450 humanized mouse model to refine schistosomiasis drug discovery. Proceedings of the National Academy of Sciences 123, e2600197123. https://doi.org/10.1073/PNAS.2600197123

Zhang, H., Marquart, B.M., Holbrook, E.M., Wright, C.T.O., Zambrano, C.A., Gebert, M.J., Dawud, L.M., Andersen, N.D., Kessler, L.R., Sago, S.A., Cole, E.Y., Costanza-Chavez, G.W., Baratta, M. V., Frank, M.G., MacDonald, A.S., Stamper, C.E., Bohr, A.D., Fierer, N., Lowry, C.A., 2026. A novel soil-derived Mycolicibacterium decreases anxiety-like defensive behavioral responses in association with decreases in biomarkers of neuroinflammation and hippocampal microglial priming in adult male rats. Brain Behav. Immun. 106809. https://doi.org/10.1016/J.BBI.2026.106809

Colombo, S.A.P., Gago, S., Chamula, M., Lord, R., MacDonald, A.S., Kosmidis, C., 2025. Dendritic cell dysfunction, including impaired IL-12 production, is associated with chronic pulmonary aspergillosis. Clin Exp Immunol 219, 38. https://doi.org/10.1093/CEI/UXAF038

Cook, P.C., Brown, S.L., Houlder, E.L., Furlong-Silva, J., Conn, D.P., Colombo, S.A.P., Baker, S., Svedberg, F.R., Howell, G., Bertuzzi, M., Boon, L., Konkel, J.E., Thornton, C.R., Allen, J.E., MacDonald, A.S., 2025. Mgl2+ cDC2s coordinate fungal allergic airway type 2, but not type 17, inflammation in mice. Nature Communications 16, 1–18. https://doi.org/10.1038/S41467-024-55663-3

Driciru, E., Koopman, J.P.R., Steenbergen, S., Sonnet, F., Stam, K.A., Bes-Roeleveld, L. de, Iliopoulou, E., Janse, J.J., Sijtsma, J., Nambuya, I., Hilt, S.T., König, M., Kruize, Y., Casacuberta-Partal, M., Egesa, M., van Dam, G.J., Corstjens, P.L.A.M., van Lieshout, L., Mpairwe, H., MacDonald, A.S., Yazdanbakhsh, M., Elliott, A.M., Roestenberg, M., Houlder, E.L., 2025. T cell responses in repeated controlled human schistosome infection compared to natural exposure. Nature Communications 16, 1–11. https://doi.org/10.1038/S41467-025-62144-8

Houlder, E.L., Gago, S., Vere, G., Furlong-Silva, J., Conn, D., Hickey, E., Khan, S., Thomson, D., Shepherd, M.W., Lebedinec, R., Brown, G.D., Horsnell, W., Bromley, M., MacDonald, A.S., Cook, P.C., 2025. Aspergillus-mediated allergic airway inflammation is triggered by dendritic cell recognition of a defined spore morphotype. Journal of Allergy and Clinical Immunology 155, 988–1001. https://doi.org/10.1016/J.JACI.2024.10.040

Ridley, A.J., Curle, A.J., P Colombo, S.A., Hughes, J.J., Dyer, D.P., Simpson, A., Booty, L.M., Feeney, M., Cook, P.C., MacDonald, A.S., Finotto, S., Cox, D.J., Wang, L., MacDonald AndrewMacDonald, A.S., 2025. The chemokines CCL22 and CCL17 are a defining feature of type 2 stimulated human lung macrophages and exhibit different metabolic dependencies. Front Immunol 16, 1654717. https://doi.org/10.3389/FIMMU.2025.1654717

Papaiakovou, M., Waeschenbach, A., Ajibola, O., Ajjampur, S.S.R., Anderson, R.M., Bailey, R., Benjamin-Chung, J., Cambra-Pellejà, M., Caro, N.R., Chaima, D., Cimino, R.O., Cools, P., Cossa, A., Dunn, J., Galagan, S., Gandasegui, J., Grau-Pujol, B., Houlder, E.L., Ibikounlé, M., Jenkins, T.P., Kalua, K., Kjetland, E.F., Krolewiecki, A.J., Levecke, B., Luty, A.J.F., MacDonald, A.S., Mandomando, I., Manuel, M., Martínez-Valladares, M., Mejia, R., Mekonnen, Z., Messa, A., Mpairwe, H., Muchisse, O., Muñoz, J., Mwinzi, P., Novela, V., Odiere, M.R., Sacoor, C., Walson, J.L., Williams, S.A., Witek-McManus, S., Littlewood, D.T.J., Cantacessi, C., Doyle, S.R., 2025. Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets. Nature Communications 16, 1–13. https://doi.org/10.1038/S41467-025-61687-0

Plumpton, E.L., Colombo, S.A.P., Steward, M., Brown, S.L., Khan, S., Tavernier, G., Francis, H., Platt, H., Hussell, T., Horsnell, W.G.C., Denning, D.W., Niven, R., Simpson, A., MacDonald, A.S., Cook, P.C., 2025. Activation status of airway immune cells is a defining feature of severe asthma, regardless of fungal sensitisation. Mucosal Immunol. https://doi.org/10.1016/j.mucimm.2025.11.004

Parkinson, J.E., Tompkins, H.E., Chakraborty, A., Burgess, M.O., Dodd, R.J., Adamson, A.D., Macdonald, A.S., Gibbs, J.E., Durrington, H.J., Allen, J.E., Sutherland, T.E., 2025. Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins. Sci Immunol 10. https://doi.org/10.1126/SCIIMMUNOL.ADK6707

Shorthouse, O., Costain, A.H., MacDonald, A.S., Quintana, J.F., 2025. The female reproductive tract-gut axis in gastrointestinal parasitic infection. PLoS Pathog. 21, e1013711. https://doi.org/10.1371/journal.ppat.1013711

Stylianou, M., Kisby, T., Despotopoulou, D., Parker, H., Thawley, A., Arashvand, K., Lozano, N., MacDonald, A.S., Kostarelos, K., 2025. Engineering the glioblastoma microenvironment using TLR7/8 agonist-complexed graphene oxide nanosheets. Cell Rep Phys Sci 6, 102342. https://doi.org/10.1016/j.xcrp.2024.102342

Su, K., Jokl, E., Costain, A., Simpson, K., Cheeseman, A., Phythian-Adams, A., Couper, K.N., MacDonald, A.S., Hanley, K.P., 2025. SOX9 plays an essential role in myofibroblast driven hepatic granuloma integrity and parenchymal repair during schistosomiasis-induced liver damage. PLoS Pathog 21, e1012928. https://doi.org/10.1371/JOURNAL.PPAT.1012928

Desmond, L.W., Holbrook, E.M., Wright, C.T.O., Zambrano, C.A., Stamper, C.E., Bohr, A.D., Frank, M.G., Podell, B.K., Moreno, J.A., MacDonald, A.S., Reber, S.O., Hernández-Pando, R., Lowry, C.A., 2024. Effects of Mycobacterium vaccae NCTC 11659 and Lipopolysaccharide Challenge on Polarization of Murine BV-2 Microglial Cells. Int J Mol Sci 25, 474. https://doi.org/10.3390/IJMS25010474/S1

Dookie, R.S., Villegas-Mendez, A., Cheeseman, A., Jones, A.P., Barroso, R., Barrett, J.R., Draper, S.J., Janse, C.J., Grogan, J.L., MacDonald, A.S., Couper, K.N., 2024. Synergistic blockade of TIGIT and PD-L1 increases type-1 inflammation and improves parasite control during murine blood-stage Plasmodium yoelii non-lethal infection. Infect Immun 92. https://doi.org/10.1128/IAI.00345-24

Mandolfo, O., Parker, H., Usman, A., Learmonth, Y.I., Holley, R.J., MacDonald, A., McKay, T., Bigger, B., 2024. Generation of a novel immunodeficient mouse model of Mucopolysaccharidosis type IIIA to test human stem cell-based therapies. Mol Genet Metab 143, 108533. https://doi.org/10.1016/J.YMGME.2024.108533

Stark, K.A., Rinaldi, G., Costain, A., Clare, S., Tolley, C., Almeida, A., McCarthy, C., Harcourt, K., Brandt, C., Lawley, T.D., Berriman, M., MacDonald, A.S., Forde-Thomas, J.E., Hulme, B.J., Hoffmann, K.F., Cantacessi, C., Cortés, A., 2024. Gut microbiota and immune profiling of microbiota-humanised versus wildtype mouse models of hepatointestinal schistosomiasis. Anim Microbiome 6, 1–19. https://doi.org/10.1186/S42523-024-00318-3

Colombo, S.A.P., Brown, S.L., Hepworth, M.R., Hankinson, J., Granato, F., Kitchen, S.J., Hussell, T., Simpson, A., Cook, P.C., MacDonald, A.S., 2023. Comparative phenotype of circulating versus tissue immune cells in human lung and blood compartments during health and disease. Discovery Immunology 2, 1–16. https://doi.org/10.1093/DISCIM/KYAD009

Finlay, C.M., Parkinson, J.E., Zhang, L., Chan, B.H.K., Ajendra, J., Chenery, A., Morrison, A., Kaymak, I., Houlder, E.L., Murtuza Baker, S., Dickie, B.R., Boon, L., Konkel, J.E., Hepworth, M.R., MacDonald, A.S., Randolph, G.J., Rückerl, D., Allen, J.E., 2023. T helper 2 cells control monocyte to tissue-resident macrophage differentiation during nematode infection of the pleural cavity. Immunity 56, 1064-1081.e10. https://doi.org/10.1016/j.immuni.2023.02.016

Holbrook, E.M., Zambrano, C.A., Wright, C.T.O., Dubé, E.M., Stewart, J.R., Sanders, W.J., Frank, M.G., MacDonald, A.S., Reber, S.O., Lowry, C.A., 2023. Mycobacterium vaccae NCTC 11659, a Soil-Derived Bacterium with Stress Resilience Properties, Modulates the Proinflammatory Effects of LPS in Macrophages. Int J Mol Sci 24, 5176. https://doi.org/10.3390/IJMS24065176

Houlder, E.L., Costain, A.H., Nambuya, I., Brown, S.L., Koopman, J.P.R., Langenberg, M.C.C., Janse, J.J., Hoogerwerf, M.A., Ridley, A.J.L., Forde-Thomas, J.E., Colombo, S.A.P., Winkel, B.M.F., Galdon, A.A., Hoffmann, K.F., Cook, P.C., Roestenberg, M., Mpairwe, H., MacDonald, A.S., 2023. Pulmonary inflammation promoted by type-2 dendritic cells is a feature of human and murine schistosomiasis. Nat Commun 14, 1–12. https://doi.org/10.1038/S41467-023-37502-Z

Ridley, A.J.L., Ou, Y., Karlsson, R., Pun, N., Birchenough, H.L., Mulholland, I.Z., Birch, M.L., MacDonald, A.S., Jowitt, T.A., Lawless, C., Miller, R.L., Dyer, D.P., 2023. Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycans. Sci Signal 16. https://doi.org/10.1126/SCISIGNAL.ADF2537

Stark, K.A., Rinaldi, G., Cortés, A., Costain, A., MacDonald, A.S., Cantacessi, C., 2023. The role of the host gut microbiome in the pathophysiology of schistosomiasis. Parasite Immunol 45, e12970. https://doi.org/10.1111/PIM.12970

Bain, C.C., Louwe, P.A., Steers, N.J., Bravo-Blas, A., Hegarty, L.M., Pridans, C., Milling, S.W.F., MacDonald, A.S., Rückerl, D., Jenkins, S.J., 2022. CD11c identifies microbiota and EGR2-dependent MHCII+ serous cavity macrophages with sexually dimorphic fate in mice. Eur J Immunol 52, 1243–1257. https://doi.org/10.1002/EJI.202149756

Bain, C.C., MacDonald, A.S., 2022. The impact of the lung environment on macrophage development, activation and function: diversity in the face of adversity. Mucosal Immunol 15, 223–234. https://doi.org/10.1038/S41385-021-00480-W

Colombo, S.A.P., Hashad, R., Denning, D.W., Kumararatne, D.S., Ceron-Gutierrez, L., Barcenas-Morales, G., MacDonald, A.S., Harris, C., Doffinger, R., Kosmidis, C., 2022. Defective Interferon-Gamma Production Is Common in Chronic Pulmonary Aspergillosis. J Infect Dis 225, 1822–1831. https://doi.org/10.1093/INFDIS/JIAB583

Costain, A.H., Phythian-Adams, A.T., Colombo, S.A.P., Marley, A.K., Owusu, C., Cook, P.C., Brown, S.L., Webb, L.M., Lundie, R.J., Smits, H.H., Berriman, M., MacDonald, A.S., 2022. Dynamics of Host Immune Response Development During Schistosoma mansoni Infection. Front Immunol 13, 906338. https://doi.org/10.3389/FIMMU.2022.906338

Hulme, H., Meikle, L.M., Strittmatter, N., Swales, J., Hamm, G., Brown, S.L., Milling, S., Macdonald, A.S., Goodwin, R.J.A., Burchmore, R., Wall, D.M., 2022. Mapping the Influence of the Gut Microbiota on Small Molecules across the Microbiome Gut Brain Axis. J Am Soc Mass Spectrom 33, 649–659. https://doi.org/10.1021/JASMS.1C00298

Lo, J.W., de Mucha, M.V., Henderson, S., Roberts, L.B., Constable, L.E., Garrido-Mesa, N., Hertweck, A., Stolarczyk, E., Houlder, E.L., Jackson, I., MacDonald, A.S., Powell, N., Neves, J.F., Howard, J.K., Jenner, R.G., Lord, G.M., 2022. A population of naive-like CD4+ T cells stably polarized to the TH1 lineage. Eur J Immunol 52, 566–581. https://doi.org/10.1002/EJI.202149228

Parker, H., Gravagnuolo, A.M., Vranic, S., Crica, L.E., Newman, L., Carnell, O., Bussy, C., Dookie, R.S., Prestat, E., Haigh, S.J., Lozano, N., Kostarelos, K., MacDonald, A.S., 2022. Graphene oxide modulates dendritic cell ability to promote T cell activation and cytokine production. Nanoscale 14, 17297–17314. https://doi.org/10.1039/D2NR02169B

Chenery, A.L., Rosini, S., Parkinson, J.E., Ajendra, J., Herrera, J.A., Lawless, C., Chan, B.H.K., Loke, P., MacDonald, A.S., Kadler, K.E., Sutherland, T.E., Allen, J.E., 2021. IL-13 deficiency exacerbates lung damage and impairs epithelial-derived type 2 molecules during nematode infection. Life Sci Alliance 4. https://doi.org/10.26508/LSA.202001000

Houlder, E.L., Costain, A.H., Cook, P.C., MacDonald, A.S., 2021. Schistosomes in the Lung: Immunobiology and Opportunity. Front Immunol 12, 635513. https://doi.org/10.3389/FIMMU.2021.635513

Minns, D., Smith, K.J., Alessandrini, V., Hardisty, G., Melrose, L., Jackson-Jones, L., MacDonald, A.S., Davidson, D.J., Gwyer Findlay, E., 2021. The neutrophil antimicrobial peptide cathelicidin promotes Th17 differentiation. Nat Commun 12, 1–16. https://doi.org/10.1038/S41467-021-21533-5

Webb, L.M., Phythian-Adams, A.T., Costain, A.H., Brown, S.L., Lundie, R.J., Forde-Thomas, J., Cook, P.C., Jackson-Jones, L.H., Marley, A.K., Smits, H.H., Hoffmann, K.F., Wojno, E.D.T., MacDonald, A.S., 2021. Plasmacytoid dendritic cells facilitate T helper cell cytokine responses throughout Schistosoma mansoni infection. Immunohorizons 5, 721. https://doi.org/10.4049/IMMUNOHORIZONS.2100071

Cortés, A., Clare, S., Costain, A., Almeida, A., McCarthy, C., Harcourt, K., Brandt, C., Tolley, C., Rooney, J., Berriman, M., Lawley, T., MacDonald, A.S., Rinaldi, G., Cantacessi, C., 2020. Baseline Gut Microbiota Composition Is Associated With Schistosoma mansoni Infection Burden in Rodent Models. Front Immunol 11, 593838. https://doi.org/10.3389/FIMMU.2020.593838

Dookie, R.S., Villegas-Mendez, A., Kroeze, H., Barrett, J.R., Draper, S.J., Franke-Fayard, B.M., Janse, C.J., MacDonald, A.S., Couper, K.N., 2020. Combinatorial Tim-3 and PD-1 activity sustains antigen-specific Th1 cell numbers during blood-stage malaria. Parasite Immunol 42, e12723. https://doi.org/10.1111/PIM.12723

Gajdasik, D.W., Gaspal, F., Halford, E.E., Fiancette, R., Dutton, E.E., Willis, C., Rückert, T., Romagnani, C., Gerard, A., Bevington, S.L., MacDonald, A.S., Botto, M., Vyse, T., Withers, D.R., 2020. Th1 responses in vivo require cell-specific provision of OX40L dictated by environmental cues. Nat Commun 11, 1–15. https://doi.org/10.1038/S41467-020-17293-3

Haziq Saliman, N., Morgan, P.B., MacDonald, A.S., Maldonado-Codina, C., 2020. Subclinical inflammation of the ocular surface in soft contact lens wear. Cornea 39, 146–154. https://doi.org/10.1097/ICO.0000000000002192

Hilligan, K.L., Tang, S.C., Hyde, E.J., Roussel, E., Mayer, J.U., Yang, J., Wakelin, K.A., Schmidt, A.J., Connor, L.M., Sher, A., MacDonald, A.S., Ronchese, F., 2020. Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles. Nat Commun 11, 1–14. https://doi.org/10.1038/S41467-020-19463-9

Hulme, H., Meikle, L.M., Strittmatter, N., van der Hooft, J.J.J., Swales, J., Bragg, R.A., Villar, V.H., Ormsby, M.J., Barnes, S., Brown, S.L., Dexter, A., Kamat, M.T., Komen, J.C., Walker, D., Milling, S., Osterweil, E.K., MacDonald, A.S., Schofield, C.J., Tardito, S., Bunch, J., Douce, G., Edgar, J.M., Edrada-Ebel, R.A., Goodwin, R.J.A., Burchmore, R., Wall, D.M., 2020. Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication. Sci Adv 6. https://doi.org/10.1126/SCIADV.AAX6328

Jones, G.R., Brown, S.L., Phythian-Adams, A.T., Ivens, A.C., Cook, P.C., MacDonald, A.S., 2020. The Methyl-CpG-Binding Protein Mbd2 Regulates Susceptibility to Experimental Colitis via Control of CD11c+ Cells and Colonic Epithelium. Front Immunol 11, 486207. https://doi.org/10.3389/FIMMU.2020.00183

Kleen, T.O., Galdon, A.A., MacDonald, A.S., Dalgleish, A.G., 2020. Mitigating Coronavirus Induced Dysfunctional Immunity for At-Risk Populations in COVID-19: Trained Immunity, BCG and “New Old Friends.” Front Immunol 11, 564048. https://doi.org/10.3389/FIMMU.2020.02059

Mayer, J.U., Brown, S.L., MacDonald, A.S., Milling, S.W., 2020. Defined Intestinal Regions Are Drained by Specific Lymph Nodes That Mount Distinct Th1 and Th2 Responses Against Schistosoma mansoni Eggs. Front Immunol 11, 592325. https://doi.org/10.3389/FIMMU.2020.592325

Bancroft, A.J., Levy, C.W., Jowitt, T.A., Hayes, K.S., Thompson, S., Mckenzie, E.A., Ball, M.D., Dubaissi, E., France, A.P., Bellina, B., Sharpe, C., Mironov, A., Brown, S.L., Cook, P.C., S. MacDonald, A., Thornton, D.J., Grencis, R.K., 2019. The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function. Nat Commun 10, 1–11. https://doi.org/10.1038/S41467-019-09996-Z

Obieglo, K., Costain, A., Webb, L.M., Ozir-Fazalalikhan, A., Brown, S.L., MacDonald, A.S., Smits, H.H., 2019. Type I interferons provide additive signals for murine regulatory B cell induction by Schistosoma mansoni eggs. Eur J Immunol 49, 1226–1234. https://doi.org/10.1002/EJI.201847858

Svedberg, F.R., Brown, S.L., Krauss, M.Z., Campbell, L., Sharpe, C., Clausen, M., Howell, G.J., Clark, H., Madsen, J., Evans, C.M., Sutherland, T.E., Ivens, A.C., Thornton, D.J., Grencis, R.K., Hussell, T., Cunoosamy, D.M., Cook, P.C., MacDonald, A.S., 2019. The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation. Nat Immunol 20, 571–580. https://doi.org/10.1038/S41590-019-0352-Y

Yu, K., Youshani, A.S., Wilkinson, F.L., O’Leary, C., Cook, P., Laaniste, L., Liao, A., Mosses, D., Waugh, C., Shorrock, H., Pathmanaban, O., Macdonald, A., Kamaly-Asl, I., Roncaroli, F., Bigger, B.W., 2019. A nonmyeloablative chimeric mouse model accurately defines microglia and macrophage contribution in glioma. Neuropathol Appl Neurobiol 45, 119–140. https://doi.org/10.1111/NAN.12489

Costain, A.H., MacDonald, A.S., Smits, H.H., 2018. Schistosome Egg Migration: Mechanisms, Pathogenesis and Host Immune Responses. Front Immunol 9, 424814. https://doi.org/10.3389/FIMMU.2018.03042

Hopwood, T.W., Hall, S., Begley, N., Forman, R., Brown, S., Vonslow, R., Saer, B., Little, M.C., Murphy, E.A., Hurst, R.J., Ray, D.W., MacDonald, A.S., Brass, A., Bechtold, D.A., Gibbs, J.E., Loudon, A.S., Else, K.J., 2018. The circadian regulator BMAL1 programmes responses to parasitic worm infection via a dendritic cell clock. Sci Rep 8, 1–13. https://doi.org/10.1038/S41598-018-22021-5

Jenkins, T.P., Peachey, L.E., Ajami, N.J., MacDonald, A.S., Hsieh, M.H., Brindley, P.J., Cantacessi, C., Rinaldi, G., 2018. Schistosoma mansoni infection is associated with quantitative and qualitative modifications of the mammalian intestinal microbiota. Sci Rep 8, 1–10. https://doi.org/10.1038/S41598-018-30412-X

Jones, G.R., Bain, C.C., Fenton, T.M., Kelly, A., Brown, S.L., Ivens, A.C., Travis, M.A., Cook, P.C., MacDonald, A.S., 2018. Dynamics of colon monocyte and macrophage activation during colitis. Front Immunol 9, 415592. https://doi.org/10.3389/FIMMU.2018.02764

May, S., Owen, H., Phesse, T.J., Greenow, K.R., Jones, G.R., Blackwood, A., Cook, P.C., Towers, C., Gallimore, A.M., Williams, G.T., Stürzl, M., Britzen-Laurent, N., Sansom, O.J., MacDonald, A.S., Bird, A.P., Clarke, A.R., Parry, L., 2018. Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation. J Pathol 245, 270–282. https://doi.org/10.1002/PATH.5074

Melo-Gonzalez, F., Fenton, T.M., Forss, C., Smedley, C., Goenka, A., MacDonald, A.S., Thornton, D.J., Travis, M.A., 2018. Intestinal mucin activates human dendritic cells and IL-8 production in a glycan-specific manner. Journal of Biological Chemistry 293, 8543–8553. https://doi.org/10.1074/jbc.M117.789305

Montanari, E., Gennari, A., Pelliccia, M., Manzi, L., Donno, R., Oldham, N.J., Macdonald, A., Tirelli, N., 2018. Tyrosinase-Mediated Bioconjugation. A Versatile Approach to Chimeric Macromolecules. Bioconjug Chem 29, 2550–2560. https://doi.org/10.1021/ACS.BIOCONJCHEM.8B00227

O’Sullivan, J.D.B., Behnsen, J., Starborg, T., MacDonald, A.S., Phythian-Adams, A.T., Else, K.J., Cruickshank, S.M., Withers, P.J., 2018. X-ray micro-computed tomography (μCT): an emerging opportunity in parasite imaging. Parasitology 145, 848–854. https://doi.org/10.1017/S0031182017002074

Pariollaud, M., Gibbs, J.E., Hopwood, T.W., Brown, S., Begley, N., Vonslow, R., Poolman, T., Guo, B., Saer, B., Jones, D.H., Tellam, J.P., Bresciani, S., Tomkinson, N.C.O., Wojno-Picon, J., Cooper, A.W.J., Daniels, D.A., Trump, R.P., Grant, D., Zuercher, W., Willson, T.M., MacDonald, A.S., Bolognese, B., Podolin, P.L., Sanchez, Y., Loudon, A.S.I., Ray, D.W., 2018. Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation. J Clin Invest 128, 2281–2296. https://doi.org/10.1172/JCI93910

Walwyn-Brown, K., Guldevall, K., Saeed, M., Pende, D., Önfelt, B., MacDonald, A.S., Davis, D.M., 2018. Human NK Cells Lyse Th2-Polarizing Dendritic Cells via NKp30 and DNAM-1. The Journal of Immunology 201, 2028–2041. https://doi.org/10.4049/JIMMUNOL.1800475

Athwal, V.S., Pritchett, J., Llewellyn, J., Martin, K., Camacho, E., Raza, S.M., Phythian‐Adams, A., Birchall, L.J., Mullan, A.F., Su, K., Pearmain, L., Dolman, G., Zaitoun, A.M., Friedman, S.L., MacDonald, A., Irving, W.L., Guha, I.N., Hanley, N.A., Hanley, K.P., 2017. SOX9 predicts progression toward cirrhosis in patients while its loss protects against liver fibrosis. EMBO Mol Med 9, 1696–1710. https://doi.org/10.15252/EMMM.201707860

Grabiec, A.M., Denny, N., Doherty, J.A., Happonen, K.E., Hankinson, J., Connolly, E., Fife, M.E., Fujimori, T., Fujino, N., Goenka, A., Holden, S., Tavernier, G., Shah, R., Cook, P.C., MacDonald, A.S., Niven, R.M., Dahlbäck, B., Fowler, S.J., Simpson, A., Hussell, T., 2017. Diminished airway macrophage expression of the Axl receptor tyrosine kinase is associated with defective efferocytosis in asthma. Journal of Allergy and Clinical Immunology 140, 1144-1146.e4. https://doi.org/10.1016/J.JACI.2017.03.024

Kannan, Y., Li, Y., Coomes, S.M., Okoye, I.S., Pelly, V.S., Sriskantharajah, S., Gückel, E., Webb, L., Czieso, S., Nikolov, N., MacDonald, A.S., Ley, S.C., Wilson, M.S., 2017. Tumor progression locus 2 reduces severe allergic airway inflammation by inhibiting Ccl24 production in dendritic cells. Journal of Allergy and Clinical Immunology 139, 655-666.e7. https://doi.org/10.1016/J.JACI.2016.05.031

Mayer, J.U., Demiri, M., Agace, W.W., MacDonald, A.S., Svensson-Frej, M., Milling, S.W., 2017. Different populations of CD11b+ dendritic cells drive Th2 responses in the small intestine and colon. Nat Commun 8, 15820. https://doi.org/10.1038/NCOMMS15820

McFarlane, A.J., McSorley, H.J., Davidson, D.J., Fitch, P.M., Errington, C., Mackenzie, K.J., Gollwitzer, E.S., Johnston, C.J.C., MacDonald, A.S., Edwards, M.R., Harris, N.L., Marsland, B.J., Maizels, R.M., Schwarze, J., 2017. Enteric helminth-induced type I interferon signaling protects against pulmonary virus infection through interaction with the microbiota. Journal of Allergy and Clinical Immunology 140, 1068-1078.e6. https://doi.org/10.1016/J.JACI.2017.01.016

Webb, L.M., Lundie, R.J., Borger, J.G., Brown, S.L., Connor, L.M., Cartwright, A.N., Dougall, A.M., Wilbers, R.H., Cook, P.C., Jackson‐Jones, L.H., Phythian‐Adams, A.T., Johansson, C., Davis, D.M., Dewals, B.G., Ronchese, F., MacDonald, A.S., 2017. Type I interferon is required for T helper (Th) 2 induction by dendritic cells. EMBO J 36, 2404–2418. https://doi.org/10.15252/EMBJ.201695345

Cook, P.C., MacDonald, A.S., 2016. Dendritic cells in lung immunopathology. Semin Immunopathol 38, 449–460. https://doi.org/10.1007/S00281-016-0571-3

Jackson-Jones, L.H., Rückerl, D., Svedberg, F., Duncan, S., Maizels, R.M., Sutherland, T.E., Jenkins, S.J., McSorley, H.J., Bénézech, C., MacDonald, A.S., Allen, J.E., 2016. IL-33 delivery induces serous cavity macrophage proliferation independent of interleukin-4 receptor alpha. Eur J Immunol 46, 2311–2321. https://doi.org/10.1002/EJI.201646442

Lundie, R.J., Webb, L.M., Marley, A.K., Phythian-Adams, A.T., Cook, P.C., Jackson-Jones, L.H., Brown, S., Maizels, R.M., Boon, L., O’Keeffe, M., MacDonald, A.S., 2016. A central role for hepatic conventional dendritic cells in supporting Th2 responses during helminth infection. Immunol Cell Biol 94, 400–410. https://doi.org/10.1038/ICB.2015.114

Pelly, V.S., Kannan, Y., Coomes, S.M., Entwistle, L.J., Rückerl, D., Seddon, B., Macdonald, A.S., Mckenzie, A., Wilson, M.S., 2016. IL-4-producing ILC2s are required for the differentiation of TH2 cells following Heligmosomoides polygyrus infection. Mucosal Immunol 9, 1407–1417. https://doi.org/10.1038/MI.2016.4

Seoane, P.I., Rückerl, D., Casaravilla, C., Barrios, A.A., Pittini, Á., MacDonald, A.S., Allen, J.E., Diáz, A., 2016. Particles from the Echinococcus granulosus laminated layer inhibit IL-4 and growth factor-driven Akt phosphorylation and proliferative responses in macrophages. Sci Rep 6, 1–13. https://doi.org/10.1038/SREP39204

Zhang, X., Cook, P.C., Zindy, E., Williams, C.J., Jowitt, T.A., Streuli, C.H., MacDonald, A.S., Redondo-Muñoz, J., 2016. Integrin α4β1 controls G9a activity that regulates epigenetic changes and nuclear properties required for lymphocyte migration. Nucleic Acids Res 44, 3031–3044. https://doi.org/10.1093/NAR/GKV1348

Besusso, D., Saul, L., Leech, M.D., O’Connor, R.A., MacDonald, A.S., Anderton, S.M., Mellanby, R.J., 2015. 1,25-dihydroxyvitamin D3-conditioned CD11c+ dendritic cells are effective initiators of CNS autoimmune disease. Front Immunol 6, 167734. https://doi.org/10.3389/FIMMU.2015.00575

Cook, P.C., Owen, H., Deaton, A.M., Borger, J.G., Brown, S.L., Clouaire, T., Jones, G.R., Jones, L.H., Lundie, R.J., Marley, A.K., Morrison, V.L., Phythian-Adams, A.T., Wachter, E., Webb, L.M., Sutherland, T.E., Thomas, G.D., Grainger, J.R., Selfridge, J., McKenzie, A.N.J., Allen, J.E., Fagerholm, S.C., Maizels, R.M., Ivens, A.C., Bird, A., Macdonald, A.S., 2015. A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells. Nat Commun 6, 1–11. https://doi.org/10.1038/NCOMMS7920

Fujimori, T., Grabiec, A.M., Kaur, M., Bell, T.J., Fujino, N., Cook, P.C., Svedberg, F.R., Macdonald, A.S., Maciewicz, R.A., Singh, D., Hussell, T., 2015. The Axl receptor tyrosine kinase is a discriminator of macrophage function in the inflamed lung. Mucosal Immunol 8, 1021–1030. https://doi.org/10.1038/mi.2014.129

Jones, L.H., Cook, P.C., Ivens, A.C., Thomas, G.D., Phythian-Adams, A.T., Allen, J.E., MacDonald, A.S., 2015. Modulation of dendritic cell alternative activation and function by the vitamin A metabolite retinoic acid. Int Immunol 27, 589–596. https://doi.org/10.1093/INTIMM/DXV020

Mylonas, K.J., Jenkins, S.J., Castellan, R.F.P., Ruckerl, D., McGregor, K., Phythian-Adams, A.T., Hewitson, J.P., Campbell, S.M., MacDonald, A.S., Allen, J.E., Gray, G.A., 2015. The adult murine heart has a sparse, phagocytically active macrophage population that expands through monocyte recruitment and adopts an ‘M2’ phenotype in response to Th2 immunologic challenge. Immunobiology 220, 924–933. https://doi.org/10.1016/J.IMBIO.2015.01.013

Redpath, S.A., van der Werf, N., MacDonald, A.S., Maizels, R.M., Taylora, M.D., 2015. Schistosoma mansoni Larvae Do Not Expand or Activate Foxp3+ Regulatory T Cells during Their Migratory Phase. Infect Immun 83, 3881–3889. https://doi.org/10.1128/IAI.00408-15

Casaravilla, C., Pittini, Á., Rückerl, D., Seoane, P.I., Jenkins, S.J., MacDonald, A.S., Ferreira, A.M., Allen, J.E., Díaz, Á., 2014. Unconventional Maturation of Dendritic Cells Induced by Particles from the Laminated Layer of Larval Echinococcus granulosus. Infect Immun 82, 3164–3176. https://doi.org/10.1128/IAI.01959-14

Deaton, A.M., Cook, P.C., De Sousa, D., Phythian-Adams, A.T., Bird, A., Macdonald, A.S., 2014. A unique DNA methylation signature defines a population of IFN-γ/IL-4 double-positive T cells during helminth infection. Eur J Immunol 44, 1835–1841. https://doi.org/10.1002/EJI.201344098

Helminth, G., Heligmosomoides, P., Reynolds, L.A., Harcus, Y., Smith, K.A., Webb, L.M., Hewitson, J.P., Ross, E.A., Brown, S., Uematsu, S., Akira, S., Gray, D., Gray, M., Macdonald, A.S., Cunningham, A.F., Maizels, R.M., 2014. MyD88 Signaling Inhibits Protective Immunity to the Gastrointestinal Helminth Parasite Heligmosomoides polygyrus. The Journal of Immunology 193, 2984–2993. https://doi.org/10.4049/JIMMUNOL.1401056

Hoy, A.M., Lundie, R.J., Ivens, A., Quintana, J.F., Nausch, N., Forster, T., Jones, F., Kabatereine, N.B., Dunne, D.W., Mutapi, F., MacDonald, A.S., Buck, A.H., 2014. Parasite-Derived MicroRNAs in Host Serum As Novel Biomarkers of Helminth Infection. PLoS Negl Trop Dis 8, e2701. https://doi.org/10.1371/JOURNAL.PNTD.0002701

Morrison, V.L., James, M.J., Grzes, K., Cook, P., Glass, D.G., Savinko, T., Lek, H.S., Gawden-Bone, C., Watts, C., Millington, O.R., MacDonald, A.S., Fagerholm, S.C., 2014. Loss of beta2-integrin-mediated cytoskeletal linkage reprogrammes dendritic cells to a mature migratory phenotype. Nat Commun 5, 1–13. https://doi.org/10.1038/NCOMMS6359

Rigby, R.E., Webb, L.M., Mackenzie, K.J., Li, Y., Leitch, A., Reijns, M.A.M., Lundie, R.J., Revuelta, A., Davidson, D.J., Diebold, S., Modis, Y., MacDonald, A.S., Jackson, A.P., 2014. RNA:DNA hybrids are a novel molecular pattern sensed by TLR9. EMBO J 33, 542–558. https://doi.org/10.1002/EMBJ.201386117

Robson, N.C., Hidalgo, L., McAlpine, T., Wei, H., Martínez, V.G., Entrena, A., Melen, G.J., MacDonald, A.S., Phythian-Adams, A., Sacedón, R., Maraskovsky, E., Cebon, J., Ramírez, M., Vicente, A., Varas, A., 2014. Optimal effector functions in human natural killer cells rely upon autocrine bone morphogenetic protein signaling. Cancer Res 74, 5019–5031. https://doi.org/10.1158/0008-5472.CAN-13-2845

Mylonas, K.J., Hoeve, M.A., MacDonald, A.S., Allen, J.E., 2013. Alternative activation of macrophages by filarial nematodes is MyD88-independent. Immunobiology 218, 570–578. https://doi.org/10.1016/J.IMBIO.2012.07.006

Redpath, S.A., van der Werf, N., Cervera, A.M., Macdonald, A.S., Gray, D., Maizels, R.M., Taylor, M.D., 2013. ICOS controls Foxp3+ regulatory T-cell expansion, maintenance and IL-10 production during helminth infection. Eur J Immunol 43, 705–715. https://doi.org/10.1002/EJI.201242794

Caserta, S., Nausch, N., Sawtell, A., Drummond, R., Barr, T., MacDonald, A.S., Mutapi, F., Zamoyska, R., 2012. Chronic Infection Drives Expression of the Inhibitory Receptor CD200R, and Its Ligand CD200, by Mouse and Human CD4 T Cells. PLoS One 7, e35466. https://doi.org/10.1371/JOURNAL.PONE.0035466

Cook, P.C., Jones, L.H., Jenkins, S.J., Wynn, T.A., Allen, J.E., MacDonald, A.S., 2012. Alternatively activated dendritic cells regulate CD4+ T-cell polarization in vitro and in vivo. Proceedings of the National Academy of Sciences 109, 9977–9982. https://doi.org/10.1073/PNAS.1121231109

Ferret-Bernard, S., Castro-Borges, W., Dowle, A.A., Sanin, D.E., Cook, P.C., Turner, J.D., MacDonald, A.S., Thomas, J.R., Mountford, A.P., 2012. Plasma membrane proteomes of differentially matured dendritic cells identified by LC–MS/MS combined with iTRAQ labelling. J Proteomics 75, 938–948. https://doi.org/10.1016/J.JPROT.2011.10.010

Mellanby, R.J., Cambrook, H., Turner, D.G., O’Connor, R.A., Leech, M.D., Kurschus, F.C., MacDonald, A.S., Arnold, B., Anderton, S.M., 2012. TLR-4 ligation of dendritic cells is sufficient to drive pathogenic T cell function in experimental autoimmune encephalomyelitis. J Neuroinflammation 9, 1–5. https://doi.org/10.1186/1742-2094-9-248

Perona-Wright, G., Lundie, R.J., Jenkins, S.J., Webb, L.M., Grencis, R.K., MacDonald, A.S., 2012. Concurrent Bacterial Stimulation Alters the Function of Helminth-Activated Dendritic Cells, Resulting in IL-17 Induction. The Journal of Immunology 188, 2350–2358. https://doi.org/10.4049/JIMMUNOL.1101642

Smith, K.A., Harcus, Y., Garbi, N., Hämmerling, G.J., MacDonald, A.S., Maizels, R.M., 2012. Type 2 Innate Immunity in Helminth Infection Is Induced Redundantly and Acts Autonomously following CD11c+ Cell Depletion. Infect Immun 80, 3481–3489. https://doi.org/10.1128/IAI.00436-12

Jenkins, S.J., Ruckerl, D., Cook, P.C., Jones, L.H., Finkelman, F.D., Van Rooijen, N., MacDonald, A.S., Allen, J.E., 2011. Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation. Science (1979) 332, 1284–1288. https://doi.org/10.1126/SCIENCE.1204351

Sibilano, R., Gri, G., Frossi, B., Tripodo, C., Suzuki, R., Rivera, J., MacDonald, A.S., Pucillo, C.E., 2011. Technical Advance: Soluble OX40 molecule mimics regulatory T cell modulatory activity on FcɛRI-dependent mast cell degranulation. J Leukoc Biol 90, 831–838. https://doi.org/10.1189/JLB.1210651

Smith, K.A., Hochweller, K., Hämmerling, G.J., Boon, L., MacDonald, A.S., Maizels, R.M., 2011. Chronic helminth infection promotes immune regulation in vivo through dominance of CD11c^loCD103⁻ dendritic cells. J Immunol 186, 7098. https://doi.org/10.4049/JIMMUNOL.1003636

van der Werf, N., Redpath, S.A., Phythian-Adams, A.T., Azuma, M., Allen, J.E., Maizels, R.M., MacDonald, A.S., Taylor, M.D., 2011. Th2 responses to helminth parasites can be therapeutically enhanced by, but are not dependent upon, GITR-GITR ligand costimulation in vivo. J Immunol 187, 1411–1420. https://doi.org/10.4049/JIMMUNOL.1100834

Phythian-Adams, A.T., Cook, P.C., Lundie, R.J., Jones, L.H., Smith, K.A., Barr, T.A., Hochweller, K., Anderton, S.M., Hämmerling, G.J., Maizels, R.M., MacDonald, A.S., 2010. CD11c depletion severely disrupts Th2 induction and development in vivo. Journal of Experimental Medicine 207, 2089–2096. https://doi.org/10.1084/JEM.20100734

Perona-Wright, G., Jenkins, S.J., O’Connor, R.A., Zienkiewicz, D., McSorley, H.J., Maizels, R.M., Anderton, S.M., MacDonald, A.S., 2009. A Pivotal Role for CD40-Mediated IL-6 Production by Dendritic Cells during IL-17 Induction In Vivo. The Journal of Immunology 182, 2808–2815. https://doi.org/10.4049/JIMMUNOL.0803553

Foster, G.L., Barr, T.A., Grant, A.J., McKinley, T.J., Bryant, C.E., MacDonald, A., Gray, D., Yamamoto, M., Akira, S., Maskell, D.J., Mastroeni, P., 2008. Virulent Salmonella enterica infections can be exacerbated by concomitant infection of the host with a live attenuated S. enterica vaccine via Toll-like receptor 4-dependent interleukin-10 production with the involvement of both TRIF and MyD88. Immunology 124, 469–479. https://doi.org/10.1111/J.1365-2567.2007.02798.X

Jenkins, S.J., Perona-Wright, G., MacDonald, A.S., 2008. Full Development of Th2 Immunity Requires Both Innate and Adaptive Sources of CD154. The Journal of Immunology 180, 8083–8092. https://doi.org/10.4049/JIMMUNOL.180.12.8083

MacDonald, A.S., Maizels, R.M., 2008. Alarming dendritic cells for Th2 induction. Journal of Experimental Medicine 205, 13–17. https://doi.org/10.1084/JEM.20072665

Worsley, A.G.F., LeibundGut-Landmann, S., Slack, E., Phng, L.K., Gerhardt, H., Sousa, C.R., MacDonald, A.S., 2008. Dendritic cell expression of the Notch ligand jagged2 is not essential for Th2 response induction in vivo. Eur J Immunol 38, 1043–1049. https://doi.org/10.1002/EJI.200737335

Jenkins, S.J., Perona-Wright, G., Worsley, A.G.F., Ishii, N., MacDonald, A.S., 2007. Dendritic Cell Expression of OX40 Ligand Acts as a Costimulatory, Not Polarizing, Signal for Optimal Th2 Priming and Memory Induction In Vivo. The Journal of Immunology 179, 3515–3523. https://doi.org/10.4049/JIMMUNOL.179.6.3515

Mahajan, S., Cervera, A., MacLeod, M., Fillatreau, S., Perona-Wright, G., Meek, S., Smith, A., MacDonald, A., Gray, D., 2007. The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells. Eur J Immunol 37, 1796–1808. https://doi.org/10.1002/EJI.200636661

Perona-Wright, G., Jenkins, S.J., Crawford, A., Gray, D., Pearce, E.J., MacDonald, A.S., 2006. Distinct sources and targets of IL-10 during dendritic cell-driven Th1 and Th2 responses in vivo. Eur J Immunol 36, 2367–2375. https://doi.org/10.1002/EJI.200535722

Perona-Wright, G., Jenkins, S.J., MacDonald, A.S., 2006. Dendritic cell activation and function in response to Schistosoma mansoni. Int J Parasitol 36, 711–721. https://doi.org/10.1016/J.IJPARA.2006.02.003

Artis, D., Kane, C.M., Fiore, J., Zaph, C., Shapira, S., Joyce, K., MacDonald, A., Hunter, C., Scott, P., Pearce, E.J., 2005. Dendritic Cell-Intrinsic Expression of NF-κB1 Is Required to Promote Optimal Th2 Cell Differentiation. The Journal of Immunology 174, 7154–7159. https://doi.org/10.4049/JIMMUNOL.174.11.7154

Cervi, L., MacDonald, A.S., Kane, C., Dzierszinski, F., Pearce, E.J., 2004. Cutting Edge: Dendritic Cells Copulsed with Microbial and Helminth Antigens Undergo Modified Maturation, Segregate the Antigens to Distinct Intracellular Compartments, and Concurrently Induce Microbe-Specific Th1 and Helminth-Specific Th2 Responses. The Journal of Immunology 172, 2016–2020. https://doi.org/10.4049/JIMMUNOL.172.4.2016

La Flamme, A.C., MacDonald, A.S., Huxtable, C.R., Carroll, M., Pearce, E.J., 2003. Lack of C3 Affects Th2 Response Development and the Sequelae of Chemotherapy in Schistosomiasis. The Journal of Immunology 170, 470–476. https://doi.org/10.4049/JIMMUNOL.170.1.470

MacDonald, A.S., Loke, P., Martynoga, R., Dransfield, I., Allen, J.E., 2003. Cytokine-dependent inflammatory cell recruitment patterns in the peritoneal cavity of mice exposed to the parasitic nematode Brugia malayi. Med Microbiol Immunol 192, 33–40. https://doi.org/10.1007/S00430-002-0156-8

Shedlock, D.J., Whitmire, J.K., Tan, J., MacDonald, A.S., Ahmed, R., Shen, H., 2003. Role of CD4 T Cell Help and Costimulation in CD8 T Cell Responses During Listeria monocytogenes Infection. The Journal of Immunology 170, 2053–2063. https://doi.org/10.4049/JIMMUNOL.170.4.2053

Straw, A.D., MacDonald, A.S., Denkers, E.Y., Pearce, E.J., 2003. CD154 Plays a Central Role in Regulating Dendritic Cell Activation During Infections That Induce Th1 or Th2 Responses. The Journal of Immunology 170, 727–734. https://doi.org/10.4049/JIMMUNOL.170.2.727

MacDonald, A.S., Araujo, M.I., Pearce, E.J., 2002. Immunology of Parasitic Helminth Infections. Infect Immun 70, 427–433. https://doi.org/10.1128/IAI.70.2.427-433.2002

MacDonald, A.S., Patton, E.A., La Flamme, A.C., Araujo, M.I., Huxtable, C.R., Bauman, B., Pearce, E.J., 2002. Impaired Th2 Development and Increased Mortality During Schistosoma mansoni Infection in the Absence of CD40/CD154 Interaction. The Journal of Immunology 168, 4643–4649. https://doi.org/10.4049/JIMMUNOL.168.9.4643

MacDonald, A.S., Pearce, E.J., 2002. Cutting Edge: Polarized Th Cell Response Induction by Transferred Antigen-Pulsed Dendritic Cells Is Dependent on IL-4 or IL-12 Production by Recipient Cells. The Journal of Immunology 168, 3127–3130. https://doi.org/10.4049/JIMMUNOL.168.7.3127

MacDonald, A.S., Straw, A.D., Dalton, N.M., Pearce, E.J., 2002. Cutting Edge: Th2 Response Induction by Dendritic Cells: A Role for CD40. The Journal of Immunology 168, 537–540. https://doi.org/10.4049/JIMMUNOL.168.2.537

Falcone, F.H., Loke, P., Zang, X., MacDonald, A.S., Maizels, R.M., Allen, J.E., 2001. A Brugia malayi Homolog of Macrophage Migration Inhibitory Factor Reveals an Important Link Between Macrophages and Eosinophil Recruitment During Nematode Infection. The Journal of Immunology 167, 5348–5354. https://doi.org/10.4049/JIMMUNOL.167.9.5348

MacDonald, A.S., Straw, A.D., Bauman, B., Pearce, E.J., 2001. CD8− Dendritic Cell Activation Status Plays an Integral Role in Influencing Th2 Response Development. The Journal of Immunology 167, 1982–1988. https://doi.org/10.4049/JIMMUNOL.167.4.1982

La Flamme, A.C., MacDonald, A.S., Pearce, E.J., 2000. Role of IL-6 in Directing the Initial Immune Response to Schistosome Eggs. The Journal of Immunology 164, 2419–2426. https://doi.org/10.4049/JIMMUNOL.164.5.2419

MacDonald, A.S., Loke, P., Allen, J.E., 2000. Suppressive Antigen-Presenting Cells in Helminth Infection. Pathobiology 67, 265–268. https://doi.org/10.1159/000028107

Ng Loke, P.’, Macdonald, A.S., Allen, J.E., 2000. Antigen-presenting cells recruited by Brugia malayi induce Th2 differentiation of naïve CD4(+) T cells Eur J Immunol 30, 1127–1135. https://doi.org/10.1002/(SICI)1521-4141(200004)30:4<1127::AID-IMMU1127>3.0.CO;2-%23

Ng Loke, P.’, Macdonald, A.S., Robb, A., Maizels, R.M., Allen, J.E., 2000. Alternatively activated macrophages induced by nematode infection inhibit proliferation via cell-to-cell contact. Eur J Immunol 30, 2669–2678. https://doi.org/10.1002/1521-4141(200009)30:9%3C2669::AID-IMMU2669%3E3.0.CO;2-1

Allen, J.E., Macdonald, A.S., 1998. Profound suppression of cellular proliferation mediated by the secretions of nematodes. Parasite Immunol 20, 241–247. https://doi.org/10.1046/J.1365-3024.1998.00151.X

MacDonald, A.S., Maizels, R.M., Lawrence, R.A., Dransfield, I., Allen, J.E., 1998. Requirement for In Vivo Production of IL-4, But Not IL-10, in the Induction of Proliferative Suppression by Filarial Parasites. The Journal of Immunology 160, 1304–1312. https://doi.org/10.4049/JIMMUNOL.160.3.1304