Dr. Bethan Medina-Pritchard

Image

Bethan is from Cardiff (Wales). She studied Biochemistry at Cardiff University. She did her PhD on ubiquitination processes in the yeast S. pombe with Dr. Colin Gordon, in the MRC Human Genetics Unit (University of Edinburgh).

In the JP lab, she is interested in the structural characterisation of proteins involved in centromere maintenance.

Out of the lab, she loves cats, cooking, crafts and movies. She is also a member of the SWI (Scottish Women’s Institute)

Publications

10. Medina-Pritchard B, Lazou V, Zou J, Byron O, Maria A Abad, Rappsilber J, Heun P and Jeyaprakash AA (2020). Structural Basis for Centromere Maintenance by Drosophila CENP-A chaperone Cal1. EMBO J DOI: 10.15252/embj.2019103234 

9. Roure V, Medina-Pritchard B, Anselm E, Jeyaprakash AA and Heun, P (2019) Reconstituting Drosophila Centromere Identity in Human Cells. Cell Rep DOI: 10.1016/j.celrep.2019.08.067 

8. Leontiou I, London N, May KM, Ma Y, Grzesiak L, Medina-Pritchard B, Jeyaprakash AA, Biggins S and Hardwick KG (2019)  The Bub1-TPR Domain Directly Interacts with Mad3 to Generate a Robust Spindle Checkpoint Arrest. Current Biology DOI: 10.1016/j.cub.2019.06.011  

7. Spiller F*, Medina-Pritchard M*, Abad MA*, Wear MA, Molina O, Earnshaw WC and Jeyaprakash AA. (2017) Molecular Basis for Cdk1 Regulated Timing of Mis18 Complex Assembly and CENP-A Deposition. EMBO Rep. DOI: 10.15252/embr.201643564 (*equal contribution)

6. Abad MA, Zou J, Medina-Pritchard M, Nigg EA, Rappsilber J, Santamaria A and Jeyaprakash AA. (2016) Ska3 Ensures Timely Mitotic Progression by Interacting Directly with Microtubules and Ska1 Microtubule Binding Domain. Sci Rep. DOI: 10.1038/srep34042

5. Subramanian L*, Medina-Pritchard B*, Barton R, Spiller F, Kulasegaran-Shylini R, Radaviciute G, Allshire RC and Jeyaprakash AA. (2016) Centromere Localisation and Function of Mis18 Requires Yipee-Like Domain-Mediated Oligomerisation. EMBO Rep. DOI: 10.15252/embr.201541520 (*equal contribution)

4. Paraskevopoulos K, Kriegenburg F, Tatham MH, Rösner HI, Medina B, Larsen IB, Brandstrup R, Hardwick KG, Hay RT, Kragelund BB, Hartmann-Petersen R, Gordon C. (2014) Dss1 is a 26S proteasome ubiquitin receptor. Mol Cell. DOI: 10.1016/j.molcel.2014.09.008

3. Abad MA*, Medina B*, Santamaria A*, Zou J, Plasberg-Hill C, Madhumalar A, Jayachandran U, Redli PM, Rappsilber J, Nigg EA and Jeyaprakash AA. (2014) Structural Basis for Microtubule Recognition by the Human Kinetochore Ska complex. Nat Commun. DOI: 10.1038/ncomms3964 (*equal contribution)

2. Medina B, Paraskevopoulos K, Boehringer J, Sznajder A, Robertson M, Endicott J, Gordon C. (2012) The ubiquitin-associated (UBA) 1 domain of Schizosaccharomyces pombe Rhp23 is essential for the recognition of ubiquitin-proteasome system substrates both in vitro and in vivo. J Biol Chem. DOI: 10.1074/jbc.M112.419838

1. Rainger J, Bengani H, Campbell L, Anderson E, Sokhi K, Lam W, Riess A, Ansari M, Smithson S, Lees M, Mercer C, McKenzie K, Lengfeld T, Gener Querol B, Branney P, McKay S, Morrison H, Medina B, Robertson M, Kohlhase J, Gordon C, Kirk J, Wieczorek D, Fitzpatrick DR. (2012) Miller (Genee-Wiedemann) syndrome represents a clinically and biochemically distinct subgroup of postaxial acrofacial dysostosis associated with partial deficiency of DHODH. Hum Mol Genet. DOI: 10.1093/hmg/dds218