Granneman Lab
The role of non-coding RNAs and RNA-binding proteins in regulating rapid adaptive responses in microbes
We study post-transcriptional regulation mechanisms in budding yeast and methicillin-resistant Staphylococcus aureus, focussing on the role of non-coding RNAs and RNA-binding proteins and how they regulate adaptation to the host.
To tackle these research questions, we developed and employed high-throughput systems biology approaches for monitoring protein-RNA (CRAC), RNA-RNA (CLASH) and RNA structure (ChemModSeq) in living cells.
CRAC | CLASH | ChemModSeq
To extract all the relevant information from these high-throughput datasets, we have developed bespoke Software pipelines and tools. Moreover, for our protein-RNA interactome studies, we have collaborated for many years with UVO3 to develop much improved UV irradiation Hardware.
Latest News
Gabriele wins a prize for the best talk at the RNA UK conferences!
January 2026
Gabriele presented her work on MRSA ribonucleases at the RNA UK conference in Windermere and won the prize for the best talk! Apparently, the panel was unanimous! Congratulations!!
Maxeen Major joins the lab!
February 2026
Maxeen has joined the lab as our new MRes student to work MRSA ribonuclease, and lots of cross-linking! Learning a lot of things!
Dr. Mehak passed her viva!
December 4, 2025
Dr. Mehak passed her viva! This was followed by a massive party in the Waddington building, from which most people are still recovering....
Sofia's NNS paper got accepted in Nucleic Acids Research!
October 9, 2025
Sofia discovered that the Nrd1-Nab3-Sen1 complex plays a role in co-regulating the expression of functionally related genes and also ensures homogenous gene expression of Pic2, a mitochondrial copper transporter. These data present a novel role for transcription termination in regulating gene expression noise
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