Granneman Lab
The role of non-coding RNAs and RNA-binding proteins in regulating rapid adaptive responses in microbes
We study post-transcriptional regulation mechanisms in budding yeast and methicillin-resistant Staphylococcus aureus, focussing on the role of non-coding RNAs and RNA-binding proteins and how they regulate adaptation to the host.
To tackle these research questions, we developed and employed high-throughput systems biology approaches for monitoring protein-RNA (CRAC), RNA-RNA (CLASH) and RNA structure (ChemModSeq) in living cells.
CRAC | CLASH | ChemModSeq
To extract all the relevant information from these high-throughput datasets, we have developed bespoke Software pipelines and tools. Moreover, for our protein-RNA interactome studies, we have collaborated for many years with UVO3 to develop much improved UV irradiation Hardware.
Latest News
New yeast conditional depletion method from the Granneman lab!
June 2026
Our new yeast anchor-away method got accepted in Cell Reports Methods!
Sander got nominated for teacher of the year!
March 2026
Sander was nominated for teacher of the year. Although he did not win any prizes in the end, it was really nice to hear that his approach to teaching was appreciated.
Gabriele wins a prize for the best talk at the RNA UK conferences!
January 2026
Gabriele presented her work on MRSA ribonucleases at the RNA UK conference in Windermere and won the prize for the best talk! Apparently, the panel was unanimous! Congratulations!!
Maxeen Major joins the lab!
February 2026
Maxeen has joined the lab as our new MRes student to work MRSA ribonuclease, and lots of cross-linking! Learning a lot of things!
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