Dr Janice Murray

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Education and Short Biography

PhD (2014) and MSc (Distinction) from Edinburgh University. Manages laboratory business.

As a long-standing employee of the University of Edinburgh I am tremendously excited to be joining the Parasite Immunoepidemiology Group as their lab manager.

Previously I have studied parasite immune evasion strategies, focussing on how parasite excretory-secretory products influence the host immune response. It is widely acknowledged that the production of immune mediating molecules by parasites may be a key means by which they tailor surroundings to facilitate their prolonged survival. I look forward to applying my knowledge gained whist studying H.polygyrus and Brugia malayi to the realm of schistosomiasis infection.

Publications

Maizels RM, Gomez-Escobar N, Prieto-Lafuente L, Murray J, Aebischer T. Expression of helminth genes in Leishmania : an experimental transfection system to test immunological function. Parasite Immunol 2008;30:195-201.

Murray J, Manoury B, Balic A, Watts C, Maizels RM. Bm-CPI-2, a cystatin from Brugia malayi nematode parasites, differs from C.elegans cystatins in a specific site mediating inhibition of the antigen-processing enzyme AEP. Mol Biochem Parasitol 2005;139:197-203.

McSorley HJ, Harcus YM, Murray J, Taylor MD, Maizels RM. Expansion of Foxp3+ regulatory T cells in mice infected with the filarial parasite, Brugia malayi. . J Immunol 2008; 181: 6456-6466.

McSorley HJ, Grainger JR, Harcus YM, Murray J, Nisbet A, Knox DP, Maizels RM. daf-7-related TGF-β homologues from trichostrongyloid nematodes show contrasting life cycle expression patterns. . Parasitology 2009;in press.

Murray, J, Gregory, WF, Gomez-Escobar, N, Atmadja, A K, Maizels, RM. Expression and immune recognition of Brugia malayi VAL-1, a homologue of vespid venom allergens and Ancylostoma secreted proteins. Mol Biochem Parasitol 2001; 118: 89-96.